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    What is the Anti Nuclear Antibody (ANA) (IFA) Test?

    The Anti-nuclear Antibody (ANA) test is used to measure the amount and observe the patterns of antinuclear antibodies present in your blood. Normally, these antibodies protect the body by targeting harmful invaders like bacteria and viruses. However, in autoimmune diseases, these antibodies can mistakenly attack healthy cells, specifically targeting the cell’s nucleus, which is why they are termed antinuclear antibodies.

    The ANA test assists in diagnosing autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis by assessing these antibody levels. Physicians use the test results along with other diagnostic tests, clinical symptoms, and physical examination findings to confirm an autoimmune condition. This allows them to determine if your immune system is attacking your own body and to devise the best treatment strategy.

    For those in Gurgaon experiencing symptoms like fatigue, joint pain, or chronic rashes, an ANA test might help identify autoimmune disorders early on, enabling you to start necessary treatments sooner.

    Anti Nuclear Antibody (ANA) (IFA) Test Parameters

    The ANA IFA test focuses on two main parameters: titre value and fluorescent pattern.

    Titre Value: This measures the level of antinuclear antibodies (ANAs) in your blood. To find the titre, the blood sample is diluted incrementally until antibodies are no longer seen. The highest dilution level where antibodies can still be detected is recorded as the titre. A higher titre suggests a larger presence of antibodies, which could indicate a higher risk of autoimmune disease.

    Antibody Pattern: The test also assesses the way these antibodies attach to different parts of the cell using a fluorescent dye that glows under a microscope. This glowing pattern assists in diagnosing specific autoimmune conditions like lupus, rheumatoid arthritis, or Sjögren’s syndrome. By reviewing these patterns, doctors can decide if further tests are needed to pinpoint specific antibodies.

    The test is performed using the Indirect Immunofluorescence (IFA) technique, which allows doctors to visualize the antibody patterns and gain valuable clues for diagnosing autoimmune disorders.

    Anti Nuclear Antibody (ANA) (IFA) Test Preparation

    When scheduling an ANA test at home, please consider the following:

    • Prerequisites

    There is no need to fast before taking the ANA test.

    • Best Time to Get Tested

    The ANA test can be done at any time during the day.

    • Who Should Get an ANA Profile Test?

    Your doctor may suggest an ANA test if there's a suspicion of an autoimmune disease. This test is recommended if you have symptoms like persistent fever, skin rashes, joint or muscle pain, significant fatigue, stiffness, or swelling. The test identifies specific antibodies in your blood, helping doctors diagnose potential autoimmune disorders.

    • Cautions Before Taking the ANA Profile Test

    Generally, there are no specific precautions or preparations required before taking the ANA test.

    Why Take the Anti Nuclear Antibody (ANA) (IFA) Test?

    The ANA test checks for specific antibodies in the blood that indicate autoimmune diseases. It is commonly used to diagnose:

    • Sjögren's Syndrome: Affects tear and saliva-producing glands.

    • Systemic Lupus Erythematosus (SLE): Involves multiple body systems, including skin and joints.

    • Autoimmune Hepatitis: Causes inflammation of the liver.

    • Rheumatoid Arthritis: This leads to painful and swollen joints.

    • Addison Disease: Impacts adrenal gland function, leading to weakness and fatigue.

    • Scleroderma: A rare disorder affecting skin and organs.

    This test is recommended if you have symptoms like skin rashes, fever, joint or muscle pain, or extreme fatigue, as it helps determine if an autoimmune disease may be responsible.

    Anti Nuclear Antibody (ANA) (IFA) Test Results & Interpretation

    The ANA test is used to detect antibodies that target cell nuclei, aiding in the diagnosis of autoimmune disorders.

    • Negative Result: Indicates no detectable antibodies, suggesting a lower chance of having an autoimmune disease, but it does not completely rule it out.

    • Weakly Positive Result: A weakly positive result suggests retesting in 6-8 weeks for clearer evaluation.

    • Positive Result: Implies that antibodies are present, which could indicate an autoimmune disease, viral infection, or other medical issues.

    Positive ANA results can be further analysed based on the pattern of antibodies to identify specific conditions:

    • Cytoplasmic Patterns: Indicate potential liver disease, Sjögren's syndrome, and muscle disorders.

    • Centromere Pattern: Associated with certain types of scleroderma, involving proteins in cell division.

    • Speckled Pattern: This may be linked to lupus, Sjögren's syndrome, or rheumatoid arthritis, involving various nuclear proteins.

    • Dense Fine Speckled (DFS): Found in some healthy individuals and inflammatory diseases.

    • Nuclear Membrane Pattern: Linked with chronic fatigue syndrome and collagen-related conditions.

    • Nuclear Dot Pattern: Associated with liver diseases and rheumatic conditions, showing antibodies against specific nuclear proteins.

    • Nucleolus Pattern: Suggestive of muscle and skin diseases.

    • Homogeneous Pattern: Often seen in lupus, indicating antibodies against DNA and histones.

    A positive ANA test alone does not confirm an autoimmune disease. Additional testing and clinical assessment are required to diagnose a specific disease.

    FAQs on Anti Nuclear Antibody (ANA) (IFA) Test in Gurgaon

    The ANA test costs ₹ 1300 in Gurgaon, and includes home sample collection within 60 minutes from booking. Results are available within 120 hours.

    Yes, Orange Health Labs offers home sample collection for the ANA test in Gurgaon. The sample will be collected within 60 minutes of booking, based on availability.

    The ANA test is primarily used to diagnose autoimmune diseases like lupus and rheumatoid arthritis. The test detects antibodies that are produced by the body to invade the cells of the body suggesting a possibility of an autoimmune disease.

    The ANA Profile test does not require fasting.

    Here’s the booking process for the ANA Profile test at Orange Health Labs:

    • Search for the Test: Look up the Antinuclear Antibody/ANA test in Gurgaon or for home services on our platform, and click on Orange Health’s page.

    • Review and Confirm: After selecting the test, review the prerequisites, provide your location details, and confirm the booking by choosing a convenient time for sample collection.

    • Sample Collection: An eMedic will come to your location at the scheduled time to collect the sample.

    • Lab Analysis: The sample is sent to our ICMR-approved and NABL-accredited laboratory for processing.

    • Get Your Results: Your results will be sent via email or WhatsApp within 120 hours, and can also be accessed on our app.

    The ANA test results help indicate the likelihood of an autoimmune disease. A negative result generally means a lower risk, while a positive result suggests antibodies that could be linked to an autoimmune condition. High antibody levels may indicate more active disease and could require further investigation.

    Once you book the ANA test, Orange Health Labs will collect your sample within approximately 60 minutes. The process is quick, and you can expect your reports online within 120 hours.

    Your doctor will decide the frequency of ANA testing based on your health condition and specific needs.

    The ANA test checks for antibody levels (titre) and their specific patterns. A lower titre suggests fewer antibodies and a reduced chance of autoimmune disease, while a higher titre indicates active disease. Patterns such as homogeneous and speckled assist in diagnosing specific autoimmune diseases.

    Orange Health offers fast and reliable ANA testing throughout Gurgaon, with convenient home sample collection available in many localities such as DLF Phase 1, DLF Phase 2, DLF Phase 3, DLF Phase 4, DLF Phase 5, Sector 14, Sector 15, Sector 21, Sector 22, Sector 23, Sector 24, Sector 29, Sector 31, Sector 40, Sector 42, Sector 43, Sector 45, Sector 46, Sector 50, Sector 51, Sector 52, Sector 53, Sector 54, Sector 55, Sector 56.

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    References

    1. Medline Plus. ANA (Antinuclear Antibody) Test: MedlinePlus Medical Test [Internet]  Available from:  https://medlineplus.gov/lab-tests/ana-antinuclear-antibody-test/
    2. Antinuclear Antibodies (ANA) Test [Internet].  Available from:  https://www.columbiadoctors.org/health-library/test/antinuclear-antibodies-ana-test/
    3. Fastest Anti-nuclear Antibody (ANA) (IFA) Test in Gurgaon at Best Price + Reports in 6 Hours [Internet].  Available from:  https://www.orangehealth.in/lab-test-bangalore/anti-nuclear-antibody?utm_source=seo_search&utm_medium=google&utm_campaign=seo&utm_term=anti-nuclear-antibody