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    What is Complement 4 (C4) Level Test?

    A Complement 4 (C4) test is a simple blood test that measures the level of a protein called C4 in your blood. C4 is part of the complement system, a group of proteins that help your immune system fight infections by targeting harmful bacteria and viruses. The complement system consists of nine main proteins (C1 to C9), which work together to protect the body. The Complement 4 (C4) test is used to assess immune function and diagnose certain health conditions. Low C4 levels may indicate that the immune system is attacking healthy cells instead of harmful invaders, which happens in autoimmune diseases like lupus. It can also be linked to chronic infections, blood disorders where red blood cells break down too quickly, liver disease, malnutrition, or sudden swelling beneath the skin. High C4 levels, on the other hand, may suggest that your body is recovering from an illness or responding well to treatment. Certain digestive disorders, lung diseases, and some cancers can also elevate C4 levels.

    To get a clearer picture of your immune health, additional tests may be needed.

    If you are living in Bangalore, you might consider taking the Complement 4 (C4) test at home for convenience and quicker results.

    Complement 4 (C4) Level Test Parameters

    The Complement 4 (C4) test measures a single parameter:

    • C4 complement protein levels in the blood.

    Complement proteins work together to protect your body from harmful microorganisms like bacteria and viruses. When these proteins detect harmful substances, they activate the immune system to form the membrane attack complex (MAC), which attaches to harmful cells or microorganisms, creating a hole in their surface and causing them to break apart.

    In addition to destroying harmful cells, the complement system increases the permeability of blood vessels, allowing white blood cells to move from the bloodstream into tissues to fight infection. It helps attract more white blood cells to the infection site and stimulates phagocytosis, where immune cells like macrophages and neutrophils engulf and destroy harmful microorganisms. The system also helps clear immune complexes from the bloodstream.

    C3 and C4 are the most commonly measured complement proteins. C4 plays a crucial role in the important functions of your immune system of identifying and attacking harmful invaders like bacteria and viruses. Because of its key role in these processes, C4 is essential for your body’s ability to respond effectively to infections.

    If an issue with your immune system is suspected, blood tests are recommended to measure C3 and C4 levels. If these levels are abnormal, additional tests for other complement proteins, such as the C1 inhibitor, may be conducted to identify the underlying cause. Measuring overall complement activity can help determine if any complement proteins are missing or not functioning properly.

    Complement 4 (C4) Level Test Preparation

    Before taking the Complement 4 (C4) test, here are a few things you should know:

    Prerequisites: No fasting is required before undergoing the Complement 4 (C4) test.

    Best Time to Get Tested: There is no specific time of the day required for the C4 test. You can schedule the test at your convenience, depending on your availability.

    Who Should Get a C4 Test: The C4 test should be done in individuals with suspected autoimmune disorders like lupus, kidney issues, or chronic hepatitis, or to monitor the progression of an existing autoimmune condition.

    Cautions Before Taking C4 Test: There are no special preparations or precautions necessary before the C4 test.

    Why Take the Complement 4 (C4) Level Test?

    The Complement 4 (C4) test is typically recommended if there are signs or symptoms of an autoimmune disorder, such as lupus or rheumatoid arthritis (RA), as follows:

    • A rash in the shape of a butterfly across the cheeks

    • Mouth sores or ulcers

    • Unexplained hair loss

    • Joint pain, stiffness, or swelling

    • Persistent mild fever

    • Extreme fatigue or tiredness

    • Sensitivity to sunlight

    • Frequent headaches or dizziness

    • Swelling around the eyes, or in the hands and feet

    • Chest pain, especially when taking deep breaths

    • Numbness or discolouration in the fingers or toes, especially in cold weather or stressful situations

    The C4 test is also important for individuals who have frequent bacterial or fungal infections, as it helps assess the immune system’s ability to fight off such threats. It may also be ordered when there are concerns about kidney function or signs of chronic hepatitis.

    For those already diagnosed with an autoimmune disorder, this test helps to monitor disease progression and evaluate how well the body is responding to treatment.

    FAQs on Complement 4 (C4) Level Test in Bangalore

    The price of a Complement 4 (C4) test in Bangalore is ₹895. This cost covers hassle-free home sample collection, which will be conducted within 60 minutes after booking confirmation.

    Yes, Orange Health Labs offers home sample collection services for the Complement 4 (C4) test in Bangalore. A highly trained medical professional, called an eMedic, will reach your location within 60 minutes after test booking, depending on slot availability.

    The Complement 4 (C4) test is used to help diagnose autoimmune disorders, monitor disease progression, and assess immune function, particularly in conditions like lupus and rheumatoid arthritis.

    No, fasting is not required before undergoing a C4 blood test. However, if your doctor has given specific pre-test instructions, it is best to follow them carefully.

    To schedule a Complement 4 (C4) test at Orange Health Labs, follow these simple steps:

    • Find the test: Visit the Orange Health website or app and search for the C4 complement test.

    • Confirm booking: Fill in your details, select a convenient time slot, and proceed to confirm your appointment.

    • Sample collection: Once the test is booked, an experienced eMedic will be assigned and dispatched to collect your blood sample from your home.

    • Laboratory processing: Your sample will be analysed in an ICMR-approved, NABL-accredited laboratory for high accuracy.

    • Receive results: The test report will be sent to you via WhatsApp or email within 46 hours and will also be accessible on the Orange Health app.

    Normal C4 levels typically range between 10 to 40 mg/dL, however, this may vary slightly based on laboratory standards and testing methods used.

    Once the Complement 4 (C4) test is booked, a trained eMedic will visit your location and collect the blood sample within 60 minutes. After the sample reaches the laboratory, you can expect to receive your test report within 46 hours.

    The number of times you may need a C4 test depends on your specific health condition, medical history, and doctor’s recommendations.

    The C4 blood test evaluates only one key parameter: the level of C4 complement protein in your bloodstream.

    Orange Health Labs provides convenient home sample collection services for the C4 test across multiple regions in Bangalore. These include Adugodi, Banashankari, Bannerghatta, Basavanagudi, Bellandur, BTM Layout, Chamrajpet, Cottonpet, CV Raman Nagar, Frazer Town, Giri Nagar, Hebbal, Domlur, Hennur, Hosur, HSR Layout, Electronic City, Jakkur, Jalahalli, Jaya Nagar, Kadugodi, Kammanahalli, Kengeri, Koramangala, Mahalakshmi Layout, Madiwala, Magadi Road, Malleshwaram, Marathahalli, Mathikere, Mysore Road, Nagarbhavi, Nandhini Layout, Old Airport Road, Peenya, RT Nagar, Rajaji Nagar, Rajarajeshwari Nagar, Sadashivnagar, Sahakara Nagar, Sanjay Nagar, Sarjapur, Seshadripuram, Shanthi Nagar, Shivaji Nagar, Sri Nagar, Tyagarajnagar, Uttarahalli, Vasanth Nagar, Vidyaranyapura, Vijaya Nagar, Whitefield, Yelahanka, and Yeshwantpur.

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    References

    1. Clinic C. C4 Complement Blood Test. 2. Complement C4 (Blood). 3. Complement | Pathology Tests Explained.  Available from:  https://my.clevelandclinic.org/health/diagnostics/c4-complement-blood-test
    2. Wang H, Liu M. Complement C4, Infections, and Autoimmune Diseases. Frontiers in Immunology.  Available from:  https://pmc.ncbi.nlm.nih.gov/articles/PMC8317844/