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    What is Leptospira IgM antibodies by EIA - Serum Test?

    The Leptospira IgM test detects specific antibodies in the blood that are produced in response to an infection caused by Leptospira bacteria. These gram-negative bacteria lead to leptospirosis, a disease frequently seen in tropical environments. The bacteria are transmitted through the urine of infected animals such as rats or dogs, entering the human body via open wounds, scratches, or mucous membranes.

    Upon entry, the bacteria spread through the bloodstream in the first week, resulting in symptoms like muscle pain, fever, and headaches. During this time, the immune system starts generating IgM antibodies as a defence mechanism. These antibodies become measurable in the blood during the initial phase and may remain detectable for about 2–3 months.

    The Leptospira IgM test plays an essential role in diagnosing leptospirosis in its early stage, particularly within the first week of symptoms. It is significantly quicker than bacterial culture methods, which can take several weeks to yield results. Early diagnosis helps in effective treatment and reduces the risk of complications.

    If you are in Mumbai and have been exposed to polluted water or soil, or if you are experiencing signs like fever and muscle aches, it’s recommended to take a Leptospira IgM test in Mumbai for timely and accurate treatment.

    Leptospira IgM antibodies by EIA - Serum Test Parameters

    The Leptospira IgM antibody test measures a single parameter: the detection of IgM antibodies produced against Leptospira bacteria in the bloodstream.

    These antibodies begin to appear about 4-5 days after symptom onset and can stay present for up to five months, making the test especially valuable during the initial stages of leptospirosis.

    Leptospirosis manifests in two phases: the acute phase, which lasts 3-7 days and is marked by symptoms such as muscle aches and headaches, and the secondary phase, beginning after the second week, when the bacteria leave the bloodstream.

    While PCR testing can detect the bacteria within the first five days, the IgM test is crucial for ensuring prompt treatment. It also plays a vital role in outbreak surveillance and provides a dependable diagnostic approach for confirming leptospirosis when samples are appropriately handled and stored.

    Leptospira IgM antibodies by EIA - Serum Test Preparation

    When planning for a Leptospira IgM test, keep these points in mind:

    Prerequisites

    Fasting is generally not required before taking the Leptospira IgM test.

    Best Time to Get Tested

    There is no specific time frame for conducting the Leptospira IgM test. You can book the test based on your preferred schedule.

    Who Should Get a Leptospira IgM Test?

    This test is recommended for individuals who show symptoms like fever, muscle pain, or yellowing of the skin after contact with contaminated soil, water, or animal urine. It is especially relevant for people in flood-affected regions or those working closely with animals such as rats, cattle, or pigs.

    Cautions Before Taking Leptospira IgM Test

    No special precautions are necessary before undergoing the Leptospira IgM test.

    Why Take the Leptospira IgM antibodies by EIA - Serum Test?

    The Leptospira IgM test is ideal under the following circumstances:

    • If you’re experiencing symptoms like high fever, muscle discomfort, headaches, nausea, vomiting, or yellow skin/eyes after coming into contact with soil, water, or urine contaminated by Leptospira bacteria.

    • If your symptoms began at least six days ago, as detectable IgM antibody levels are typically present by this time. Testing becomes more precise after this period.

    • If you’re in the second week of illness when IgM antibodies reach peak levels, making this the optimal window for serological testing to confirm recent infections.

    • If you’ve been in areas with heavy rainfall or flooding where water sources are susceptible to contamination by the bacteria.

    • If you’ve been exposed to animals like rodents, cattle, pigs, or dogs that may silently carry and shed Leptospira bacteria through their urine into the environment.

    Under these conditions, the Leptospira IgM test is critical for confirming infection and initiating treatment without delay.

    FAQs on Leptospira IgM antibodies by EIA - Serum Test in Mumbai

    The Leptospira IgM test in Mumbai costs ₹1365. Home sample collection will occur within 60 minutes of confirmation, and results are provided within 145 hours after sample collection.

    Yes, Orange Health Labs offers home collection services in Mumbai. Trained eMedics will collect your sample within 60 minutes post-booking, subject to time slot availability.

    Leptospira IgM test detects IgM antibodies formed early during leptospirosis. Early detection ensures timely treatment and reduces the risk of complications.

    Fasting is not required. However, always check with your doctor for specific instructions.

    To book the Leptospira IgM test, follow these steps:

    • Choose the test: Visit the Orange Health website and select the Leptospira IgM test.

    • Book appointment: Enter your details, choose a time slot, and confirm.

    • Sample collection: A trained professional will collect your sample from your location.

    • Laboratory processing: Samples are processed in ICMR-certified, NABL-accredited labs.

    • Receive results: Reports are shared via email or WhatsApp within 145 hours after sample collection.

    Test interpretations are as follows: positive (above 11), indicating an active or recent infection; equivocal (9 to 11), reflecting uncertainty requiring follow-up; and negative (below 9), which rules out infection but may require repeat testing.

    After you book the Leptospira IgM test, the home sample collection will be performed within 60 minutes. Test results will then be sent to you within 145 hours of sample collection.

    The frequency of testing depends entirely on individual health needs and medical circumstances. Consult with your doctor for appropriate recommendations.

    This test measures one parameter, the IgM antibody levels in your blood, to detect the presence of leptospirosis infection.

    Orange Health offers home sample collection for this test across multiple Mumbai neighborhoods, including Colaba, Nariman Point, Marine Drive, Malabar Hill, Churchgate, Worli, Dadar, Parel, Byculla, Bandra, Andheri, Juhu, Ghatkopar, Powai, Chembur, Vashi, Belapur, Santacruz, Khar, Versova, Lokhandwala, Goregaon, Borivali, Kandivali, Mulund, Bhandup, Kurla.

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    References

    1. Leptospira, IgM, Serum - Mayo Clinic Laboratories | Microbiology and Infectious Disease Catalog [Internet].  Available from:  https://microbiology.testcatalog.org/show/LEPDT
    2. Rosa MI, Reis MF dos, Simon C, Dondossola E, Alexandre MC, Colonetti T, et al. IgM ELISA for leptospirosis diagnosis: a systematic review and meta-analysis. Ciência & Saúde Coletiva [Internet].  Available from:  https://www.scielo.br/j/csc/a/hrGJ8NWDdFTrnmwMGhqc8sw/?lang=en#:~:text=Traditional%20serological%20methods%2C%20such%20as
    3. Royal Australian College of General Practitioners. Leptospirosis [Internet].  Available from:  https://www.racgp.org.au/getattachment/c22e6559-81c6-4827-ab6a-109ea22a3ed9/Leptospirosis.aspx
    4. Cleveland Clinic. Leptospirosis: Causes, Symptoms, Diagnosis & Treatment [Internet].  Available from:  https://my.clevelandclinic.org/health/diseases/24021-leptospirosis