The Dengue NS1 Antigen ELISA test spots the non-structural protein 1 (NS1) of the dengue virus in a blood sample, with antigens being any foreign substances entering the body. This detection is feasible during the acute phase of dengue fever, which spans the first 7 days, facilitating early diagnosis and necessary medical treatment.

Mosquito bites are the primary means of transmission for dengue fever, which is brought on by one of the four serotypes of the dengue virus from the Flavivirus family. When bitten by an infected mosquito, the virus enters the bloodstream and starts to multiply. This virus and the immune system's reaction cause the symptoms of dengue fever. The Dengue NS1 test can identify the virus in the blood during the first 7 days of symptom appearance. Research shows that NS1 antigen levels in the blood are linked to disease severity, with higher levels observed in severe cases. Therefore, the Dengue Antigen test is a critical diagnostic tool for dengue infections.

For those in Delhi showing dengue symptoms, a Dengue Antigen test can be extremely helpful. Schedule a Dengue Antigen test in Delhi today to check your dengue status if you believe you have been exposed to the virus.

It is crucial to consider the following elements prior to having a Dengue Fever NS1 Antigen test:

Prerequisites

The Dengue NS1 test does not require fasting.

Best Time to Get Tested

The Dengue Antigen test can be administered at any time of day.

Who Should Consider a Dengue NS1 ELISA Test

The test is advised if you have been in a dengue-prone area and show symptoms such as high fever, rash, nausea, vomiting, muscle and joint pain, and pain behind the eyes.

Cautions Before Taking Dengue NS1 ELISA Test

There are no special cautions to observe before the Dengue NS1 test.

You should take a Dengue NS1 test if you live in or have been to an area where dengue fever is common and have recently been showing symptoms of dengue. The symptoms of dengue fever usually arise within 4 to 10 days after a mosquito bite and continue for 3 to 7 days. Symptoms typically include a sudden fever reaching up to 104°F or above along with any of the following symptoms:

• Rash

• Nausea and vomiting

• Severe pain behind the eyes

• Headache

• Muscle, bone, or joint pain

If neglected, some individuals may develop a life-threatening worsening of symptoms called dengue haemorrhagic fever that causes nose bleeds, bleeding gums, abdominal pain, frequent vomiting, throwing up blood, blood in stools, and extreme tiredness. The risk of severe dengue underscores the need for early detection and treatment of this infection.

Since the NS1 antigen is detectable in the blood during the acute phase of infection, the NS1 test is done in the first 7 days of experiencing symptoms. After the first week, the NS1 test may not be as sensitive in diagnosing dengue.

The Dengue Antigen test thus helps doctors with early detection of dengue, confirming dengue infection, and ruling out other non-dengue illnesses that have similar symptoms.

The below table explains the interpretation of the results of a Dengue NS1 ELISA test:

It is important to note that interference may occur in some cases where the blood sample contains antibodies against test components. For example, when testing for dengue virus, the test might also detect antibodies from cross-reactivity with other Flaviviruses or other non-infectious conditions, potentially leading to false-positive results or misinterpretation of the test. Therefore, when interpreting test results, it's essential to consider the patient's clinical history to ensure an accurate diagnosis. In such cases, using both NS1 detection and IgM Antibody tests can enhance the accuracy of diagnosing dengue infection. It’s also important to note that the dengue NS1 ELISA is the preferred test within the initial 7 days of symptom onset. After 7-10 days, dengue fever IgG and IgM antibody tests are recommended.