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    Complement 3 (C3) Level117988025% off
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    What is Complement 3 (C3) Level Test?

    A C3 complement blood test evaluates how well your immune system is functioning by measuring the amount of C3 protein in your blood. C3 is an essential component of the complement system, which helps protect your body from bacteria and viruses. However, in some cases, the complement system may mistakenly attack healthy cells, contributing to autoimmune diseases.

    This test is useful for diagnosing a range of conditions. If you experience symptoms of autoimmune disorders like lupus or suffer from recurrent infections and inflammation, it can provide critical insights. Additionally, it helps monitor treatment progress in diseases such as lupus or rheumatoid arthritis. C3 proteins support infection clearance and healing. Low C3 levels may indicate immune system dysfunction due to infections, autoimmune diseases, or other health concerns. Doctors frequently order a C3 test along with a C4 test to examine complement system issues. This aids in diagnosing conditions such as kidney disorders, vasculitis, and glomerulonephritis.

    If you reside in Delhi, a C3 blood test can help assess your immune system’s efficiency, offering your doctor a clearer understanding of your health and supporting treatment decisions.

    Complement 3 (C3) Level Test Parameters

    The C3 test evaluates a single parameter: the level of C3 complement protein in the blood. Produced by the liver, C3 circulates in the bloodstream and plays a crucial role in immune defence by targeting pathogens. Within the complement system, C3 is activated as part of a coordinated process involving a group of proteins from C1 to C9. When a pathogen invades, these proteins function in a sequence to eliminate the threat by forming a structure called the membrane attack complex (MAC). The MAC creates openings in the pathogen’s cell wall, ultimately causing its destruction. This test helps assess whether the complement system is functioning properly. Along with C4, C3 is one of the most commonly tested complement proteins. If C3 levels are abnormal, further tests may be required to examine other complement proteins. Total complement activity, measured by CH50 or CH100, evaluates the overall function of the complement system from C1 to C9. If CH50 results are abnormal, additional tests can help identify specific complement deficiencies.

    Complement 3 (C3) Level Test Preparation

    When scheduling a C3 test, keep these important factors in mind:

    Prerequisites

    No fasting is needed before undergoing the C3 test.

    Best Time to Get Tested

    There is no fixed time for this test, so you can book it whenever it is convenient for you.

    Who Should Get a C3 Test?

    This test is often recommended for individuals experiencing persistent infections, inflammation, fatigue, or joint pain. It is useful for diagnosing and monitoring autoimmune conditions such as lupus, rheumatoid arthritis, and kidney disorders.

    Cautions Before Taking C3 Test

    No specific precautions or preparations are required before taking the C3 test.

    Why Take the Complement 3 (C3) Level Test?

    A C3 complement test is useful in several medical situations:

    • Monitoring autoimmune diseases such as lupus or rheumatoid arthritis to assess whether the treatment is effective.

    • Checking for immune-related conditions like vasculitis (inflammation of blood vessels) and glomerulonephritis (a kidney disorder).

    • Tracking rare autoimmune disorders where lower complement levels indicate disease severity, helping doctors adjust treatment.

    • Investigating frequent bacterial infections to determine if the immune system is functioning properly.

    • Assessing unexplained inflammation or swelling to detect potential autoimmune disorders.

    • Diagnosing autoimmune diseases like lupus , where the immune system mistakenly targets the body's own tissues.

    By measuring C3 levels, this test provides critical insights into immune function and disease activity.

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    References

    1. C3 Complement Blood Test: What It Is, Procedure & Results [Internet]. 2. Complement Blood Test: MedlinePlus Medical Test [Internet].  Available from:  https://my.clevelandclinic.org/health/diagnostics/22138-c3-complement-blood-test
    2. Complement | Pathology Tests Explained [Internet].  Available from:  https://www.pathologytestsexplained.org.au/ptests-pro.php?q=Complement
    3. Haddad A, Wilson AM. Biochemistry, Complement [Internet].  Available from:  https://www.ncbi.nlm.nih.gov/books/NBK544229/