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    What is CD 19, Flow Cytometry Test?

    The CD19 blood test measures the level of CD19, a protein found on the surface of B cells — a type of white blood cell essential for immune function. CD19 plays a key role in regulating B cell function, supporting their growth, division, and response to infections. The CD19 protein is present in normal, healthy B cells as well as in certain cancers, especially B-cell-related cancers like leukaemia and lymphoma.

    The primary purpose of the CD19 blood test is to detect and monitor B-cell-related cancers such as:

    • B-cell Acute Lymphoblastic Leukaemia (B-ALL): A type of cancer where abnormal B cells multiply uncontrollably.

    • Chronic Lymphocytic Leukaemia (CLL): A cancer of the blood and bone marrow that primarily affects older adults.

    • B-cell Lymphomas: Cancer of the lymphatic system that involves B cells.

    Since CD19 is expressed on the surface of most B-cell tumours, this test can help find abnormal B cells and check if the disease is getting worse or spreading. CD19 levels vary across different cancers. Higher levels are found in breast, liver, pancreatic, and adrenal cancers, while lower levels are seen in cervical cancer and sarcoma, which may lead to worse outcomes. Measuring the CD19 Marker Flow Cytometry test can also help predict how well a patient may respond to treatment.

    Apart from cancer, CD19 may be linked to other conditions, such as psoriasis (a skin condition) and major depressive disorder (MDD), through specific signalling pathways that regulate immune responses.

    For individuals residing in Bangalore, getting a CD19 test at home can be convenient with prompt sample collection and delivery of results.

    CD 19, Flow Cytometry Test Parameters

    The CD19 test measures a single parameter: the presence of CD19 protein on B cells in the blood. CD19 is a protein found on the surface of B cells that plays an important role in helping B cells respond correctly to infections. CD19 works with other proteins, including the B cell receptor (BCR), to activate B cells when needed. This helps B cells grow and produce antibodies to fight infections.

    CD19 is present at different stages of B cell development, from the bone marrow where B cells are made, to the spleen where they mature. It is important for the normal function and development of B cells. In addition to its role in immunity, CD19 is found in many B-cell cancers, such as leukaemia and lymphoma, aiding in diagnosis and guiding treatment. Because CD19 is specific to B cells, it is a target for certain treatments that use the body’s own immune cells to attack cancer.

    CD 19, Flow Cytometry Test Preparation

    To prepare yourself for the CD19 test at home, the testing prerequisites are as follows:

    • Prerequisites

    There are no specific prerequisites, such as fasting, required for the CD19 test.

    • Best Time to Get Tested

    The CD19 test can be scheduled and performed at any convenient time throughout the entire day.

    • Who Should Get a CD19 Test?

    This test is highly recommended for individuals with frequent infections, suspected immune system disorders, autoimmune conditions, or B cell cancers like leukaemia and lymphoma, to assess immune health and monitor disease progression.

    • Cautions Before Taking a CD19 Test

    No special precautions need to be taken before getting the CD19 test.

    Why Take the CD 19, Flow Cytometry Test?

    The CD19 test helps find and track certain diseases, especially those affecting B cells. This test is useful for several reasons:

    • Identifying Blood Cancers: Some cancers, like acute lymphoblastic leukaemia (ALL) and chronic lymphocytic leukaemia (CLL) (both blood cancers), as well as B-cell lymphomas (a cancer of B cells), are associated with high CD19 levels. This test helps in identifying these diseases early.

    • Distinguishing Lymphoma Types : Different kinds of lymphoma (a type of blood cancer) have different CD19 levels. The test helps determine the exact type, which is important for choosing the right treatment.

    • Checking Cancer Growth : For those receiving treatment for blood cancer, the test shows if the disease is improving or getting worse over time.

    • Predicting Cancer Outcomes : Some cancers, like cervical cancer (affecting the lower part of the uterus), rectal cancer and sarcoma (a type of bone or soft tissue cancer), have low CD19 levels when the disease is more advanced. This test helps determine disease severity.

    • Studying Other Cancers : High CD19 levels have been found in cancers like breast cancer and liver cancer.

    CD19 Marker Flow Cytometry test helps diagnose, monitor, and research various cancers by detecting B-cell changes, tracking disease progression, and identifying different cancer types.

    FAQs on CD 19, Flow Cytometry Test in Bangalore

    The price of the CD19 test in Bangalore is ₹2890. This amount covers fast home sample collection within 60 minutes of booking. Results will be delivered within 70 hours after the sample is collected.

    Yes, Orange Health Labs provides home sample collection for the CD19 test. After booking, a skilled eMedic professional will visit your home within 60 minutes to gather the sample.

    A CD19 test is used to assess B cell function, helping diagnose immune system disorders, infections, and certain blood cancers like lymphoma and leukaemia.

    No, fasting is not required before the CD19 test, so you can take the test without any special preparation.

    To book a CD19 test with Orange Health Labs, follow these simple steps:

    Search for the Test : Look up the "CD19 test" and select the Orange Health Labs option from the available listings.

    Confirm Your Booking : Fill in your details, choose the correct location, and pick a suitable time for sample collection.

    Sample Collection : A certified eMedic will visit your location to collect the blood sample.

    Analysis and Results : The sample will be processed at our NABL-accredited, ICMR-approved laboratory. You’ll receive the results via email or WhatsApp within 70 hours after sample collection.

    The normal range for CD19 test results is 4.6–22.1% for % CD19 cells and 56.6–417.4 cells/µL for the absolute count of CD19 cells.

    Test results are generally available within 70 hours after the sample has been collected.

    The frequency of the CD19 test depends on your specific health condition and the advice of your doctor.

    The CD19 test measures the following parameters: the percentage and the absolute count of CD19 cells found on the surface of B cells circulating in your blood.

    The CD19 test is available in several areas across Bangalore, including but not limited to Adugodi, Banashankari, Bannerghatta, Basavanagudi, Bellandur, BTM Layout, Chamrajpet, Cottonpet, CV Raman Nagar, Frazer Town, Giri Nagar, Hebbal, Domlur, Electronic City, Hennur, Hosur, HSR Layout, Jakkur, Jalahalli, Jaya Nagar, Kadugodi, Kammanahalli, Kengeri, Koramangala, Mahalakshmi Layout, Madiwala, Magadi Road, Malleshwaram, Marathahalli, Mathikere, Mysore Road, Nagarbhavi, Nandhini Layout, Old Airport Road, Peenya, RT Nagar, Rajaji Nagar, Rajarajeshwari Nagar, Sadashivnagar, Sahakara Nagar, Sanjay Nagar, Sarjapur, Seshadripuram, Shanthi Nagar, Shivaji Nagar, Sri Nagar, Tyagarajnagar, Uttarahalli, Vasanth Nagar, Vidyaranyapura, Vijaya Nagar, Whitefield, Yelahanka, Yeshwantpur.

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    References

    1. Wang K, Wei G, Liu D. CD19: a biomarker for B cell development, lymphoma diagnosis and therapy. Experimental Hematology & Oncology.  Available from:  https://ehoonline.biomedcentral.com/articles/10.1186/2162-3619-1-36
    2. Zhou B, Wu T, Li H, Yang J, Ma Z, Ling Y, et al. Identification of CD19 as a shared biomarker via PPARγ/β-catenin/Wnt3a pathway linking psoriasis and major depressive disorder. Journal of Affective Disorders.  Available from:  https://www.sciencedirect.com/science/article/abs/pii/S0165032724013958
    3. CD19 - an overview | ScienceDirect Topics [Internet].  Available from:  https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/cd19