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    What is Acetyl Choline Receptor Binding antibody Test?

    The Acetylcholine Receptor (AChR) Antibody test is a blood test used to detect antibodies that attack acetylcholine receptors, which are essential for nerve-muscle communication. Acetylcholine is a neurotransmitter that binds to receptors on muscle cells, triggering muscle contractions. In myasthenia gravis (MG), an autoimmune disorder, the immune system produces abnormal AChR antibodies that interfere with this process, leading to muscle weakness and fatigue.

    The test is useful in diagnosing neuromuscular disorders associated with acetylcholine function in the body. The AChR antibody test is particularly useful in cases where clinical symptoms such as drooping eyelids (ptosis), muscle weakness, difficulty speaking, or breathing issues suggest MG, but further confirmation of the diagnosis is required. It is also valuable for monitoring the effectiveness of therapy in thymoma and MG, as antibody levels may decline with successful treatment.

    Individuals in Bangalore who are required to assess AChR antibody levels can conveniently schedule an Acetylcholine Receptor Antibody test at home.

    Acetyl Choline Receptor Binding antibody Test Parameters

    The AChR antibody test measures the concentration of autoantibodies against acetylcholine receptors in the blood.

    Acetylcholine is a chemical responsible for the contraction of muscles. In individuals with MG, AChR antibodies are produced, which interfere with acetylcholine function. AChR antibodies also impact the nerve cells that send signals from nerves to muscles. These antibodies contribute to neuromuscular dysfunction by blocking, destroying, or altering acetylcholine receptors at the neuromuscular junction. The antibodies are usually present in 85-90% of patients with generalised disease.

    Acetyl Choline Receptor Binding antibody Test Preparation

    Preparing for an AChR antibody test is hassle-free. The following information can help you prepare for the test:

    • Prerequisites : The test does not require any special preparations such as fasting.

    • Best Time to Get Tested : The AChR Antibody test can be scheduled at any time during the day.

    • Who Should Get an Acetylcholine Receptor Antibody Test? : This test is recommended for individuals experiencing symptoms of myasthenia gravis, such as muscle weakness, drooping eyelids, difficulty swallowing, or trouble speaking. It is also advised for those with a suspected autoimmune neuromuscular disorder or a thymoma.

    • Cautions Before Taking an Acetylcholine Receptor Antibody Test : Certain medications such as muscle relaxants or anaesthetics may affect test results. Inform your doctor about any ongoing treatments before testing.

    Why Take the Acetyl Choline Receptor Binding antibody Test?

    The AChR Antibody test is essential for diagnosing MG, an autoimmune neuromuscular disorder. Timely diagnosis through testing is crucial for managing symptoms and improving the quality of life. The test may be recommended upon presentation of symptoms like:

    • Drooping eyelids (ptosis)

    • Muscle weakness in the arms, legs, neck, and fingers

    • Speech difficulties

    • Swallowing and chewing problems

    • Breathing issues

    • Unsteady gait

    FAQs on Acetyl Choline Receptor Binding antibody Test in Bangalore

    The cost of the Acetylcholine Receptor (AChR) Antibody test in Bangalore is ₹3630. This includes home sample collection within 60 minutes, with test results available within 94 hours after sample collection.

    Yes, Orange Health Labs offers home sample collection for the AChR Antibody test. A trained eMedic will visit your location within 60 minutes of booking to collect the sample.

    The Acetylcholine Receptor Antibody test is primarily used for diagnosing myasthenia gravis by detecting the presence of antibodies that interfere with neuromuscular communication. It helps diagnose conditions like MG and thymoma and monitor treatment response.

    No, fasting is not required for the Acetylcholine Receptor Antibody test.

    To book the test with Orange Health Labs, follow these steps:

    • Search & Select: Look for the "Acetylcholine Receptor Antibody test" and choose Orange Health Labs.

    • Confirm Appointment: Enter your details, select your location, and schedule a convenient time for sample collection.

    • Sample Collection: A trained eMedic will collect the sample from your home or office.

    • Laboratory Testing: The sample will be analysed at an NABL-accredited, ICMR-approved laboratory.

    • Receive Results: Test results will be sent via email or WhatsApp within 94 hours.

    Normal levels of Acetylcholine Receptor Antibodies are <0.05nmol/L. Low or undetectable levels of AChR antibodies are considered normal, while elevated levels suggest the presence of myasthenia gravis or other neuromuscular disorders. Your doctor will interpret the results based on your symptoms and medical history.

    Test results are typically available within 94 hours after sample collection.

    The frequency of testing depends on your doctor's recommendation. This test is generally ordered when myasthenia gravis is suspected or to monitor disease progression and treatment response. Your healthcare provider will determine if repeat testing is necessary based on your condition.

    This test measures the levels of acetylcholine receptor antibodies in the blood, which play a role in blocking acetylcholine receptors at the neuromuscular junction.

    With Orange Health Labs, you can conveniently undergo the Acetylcholine Receptor Antibody test in the comfort of your home or office. You can request sample collection service at various localities in Bangalore, including but not limited to Adugodi, Banashankari, Bannerghatta, Basavanagudi, Bellandur, BTM Layout, Chamrajpet, Cottonpet, CV Raman Nagar, Frazer Town, Giri Nagar, Hebbal, Domlur, Electronic City, Hennur, Hosur, HSR Layout, Jakkur, Jalahalli, Jaya Nagar, Kadugodi, Kammanahalli, Kengeri, Koramangala, Mahalakshmi Layout, Madiwala, Magadi Road, Malleshwaram, Marathahalli, Mathikere, Mysore Road, Nagarbhavi, Nandhini Layout, Old Airport Road, Peenya, RT Nagar, Rajaji Nagar, Rajarajeshwari Nagar, Sadashivnagar, Sahakara Nagar, Sanjay Nagar, Sarjapur, Seshadripuram, Shanthi Nagar, Shivaji Nagar, Sri Nagar, Tyagarajnagar, Uttarahalli, Vasanth Nagar, Vidyaranyapura, Vijaya Nagar, Whitefield, Yelahanka, Yeshwantpur.

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    References

    1. Acetylcholine Receptor Antibody (Blood) - Health Encyclopedia - University of Rochester Medical Center.  Available from:  https://www.urmc.rochester.edu/encyclopedia/content?contenttypeid=167&contentid=acetylcholine_receptor_antibody_blood
    2. Acetylcholine receptor antibody: MedlinePlus Medical Encyclopedia.  Available from:  https://medlineplus.gov/ency/article/003576.htm
    3. Acetylcholine Receptor Antibody.  Available from:  https://www.ucsfhealth.org/medical-tests/acetylcholine-receptor-antibody
    4. Journal of Neurology Neurosurgery & Psychiatr.  Available from:  https://pmc.ncbi.nlm.nih.gov/articles/PMC490626/
    5. ‌Acetylcholine receptor antibody Information | Mount Sinai - New York.  Available from:  https://www.mountsinai.org/health-library/tests/acetylcholine-receptor-antibody